Immune System Information and Thai Climate Calculator: College News | Imperial News





Here’s a load of fresh news and announcements from across Imperial.

From information on cell signaling in the immune system to a new energy and emission model for Thailand, here is some quick-read news from across the College.

Immune cell signaling

Computer illustration of the biological structures involvedOur immune system relies on complex signaling between different cells to activate different responses. Today, Dr. Doryen Bubeck of the Department of Life Sciences and his colleagues have determined how an important component of the immune system – a ‘cytokine’ protein called interleukin 27 (IL-27) – elicits an immune response.

IL-27 is made up of two different parts called EBI3 and p28. Together, these constitute a signal that is recognized by protein receptors to control inflammation during an immune response. The team used a technique called cryo-electron microscopy to reveal in molecular detail the interaction interfaces between IL-17 and its two receptors that control signaling.

The team say the structure they discovered will provide a model for designing new therapeutic cytokines that can adjust the strength of these immune messages. They will then study how these proteins behave within a membrane.

Read the full article in EMBO reports: ‘Structural insights into the assembly and activation of the IL-27 signaling complex’

Diversity and Mentoring in Science

Title slide of a video titled Clare Yijia Xie, a recent graduate with a Bachelor of Science in Chemistry, was nominated by the National Research Foundation of Singapore to attend the 71st Lindau Nobel Laureate Meeting this year. These meetings, created in 1951, promote exchanges between generations, scientific disciplines and different cultures. At the meetings in Lindau, Germany, approximately 30-40 Nobel laureates come together to meet the next generation of leading scientists: 600 undergraduates, doctoral students and postdoctoral researchers from around the world.

In an interview during the meeting, Clare discussed the importance of diversity and mentorship in science. She shared how a professor’s mentorship during her undergraduate studies at Imperial and advice from others helped her take the next step in her academic journey. Clare is currently a research engineer at IHPC, A*STAR; she will begin her doctoral studies at Harvard University in the fall.

Watch the full video on the Lindau Nobel Laureate Meeting LinkedIn page.

Thailand Climate Calculator

Twoo men standing in front of a sigh that said 'Thailand 2050 calculator'A consortium including researchers from Imperial College London has created a bespoke energy and emissions model to help Thailand meet its climate goals.

The Thailand 2050 Calculator will help the Energy Policy and Planning Office (EPPO) of the Thai Ministry of Energy implement its climate change mitigation plan, including monitoring and evaluation of mitigation strategies greenhouse gases.

The tool will be used to develop energy-related policies to improve Thailand’s future greenhouse gas reduction measures. Furthermore, it will contribute to strengthening EPPO’s potential to analyze energy demand and supply data related to environmental aspects.

Paisan Sukpanit, postgraduate researcher at Imperial Oil’s Environmental Policy Center and lead member of the Thailand Consortium team, said: “The Thailand 2050 calculator can be an important support tool in Thailand’s transition. towards net zero emissions. The model’s ability to capture both energy and non-energy sector emissions is a major advantage in facilitating communication between organizations to address the complex challenge of climate change, which requires action from all sectors.

The interactive energy model was delivered as part of the UK government’s international 2050 Calculator programme, funded by the Department for Business, Energy and Industrial Strategy. It was led by global engineering, management and development consultancy Mott MacDonald and a consortium including Imperial College London, Climact and Ricardo.

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